Abstract
A 60-year-old male presented with multiple, purplish-red, nodules and plaques. After a complete work-up, he was diagnosed with CD4+/CD56+ hematodermic neoplasm. We review the clinical, pathological, and immunohistochemical features of this disease. CD4+/CD56+ hematodermic neoplasm, which is also known as blastic natural killer-cell lymphoma, is a rare, aggressive neoplasm with a strong predilection for skin involvement.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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CD4 Antigens / analysis
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CD56 Antigen / analysis
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Cyclophosphamide / administration & dosage
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Daunorubicin / administration & dosage
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Daunorubicin / analogs & derivatives
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Dexamethasone / administration & dosage
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Doxorubicin / administration & dosage
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Etoposide / administration & dosage
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Humans
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Immunophenotyping
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Killer Cells, Natural / pathology*
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Lymphoma, T-Cell, Cutaneous / diagnosis*
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Lymphoma, T-Cell, Cutaneous / drug therapy
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Lymphoma, T-Cell, Cutaneous / pathology
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Male
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Middle Aged
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Pruritus / etiology
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Remission Induction
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Vincristine / administration & dosage
Substances
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CD4 Antigens
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CD56 Antigen
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Vincristine
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Etoposide
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Dexamethasone
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Doxorubicin
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feudomycin D
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Cyclophosphamide
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Daunorubicin