CD4+/CD56+ Hematodermic neoplasm (plasmacytoid dendritic cell tumor)

Dermatol Online J. 2008 Nov 15;14(11):5.

Abstract

A 60-year-old male presented with multiple, purplish-red, nodules and plaques. After a complete work-up, he was diagnosed with CD4+/CD56+ hematodermic neoplasm. We review the clinical, pathological, and immunohistochemical features of this disease. CD4+/CD56+ hematodermic neoplasm, which is also known as blastic natural killer-cell lymphoma, is a rare, aggressive neoplasm with a strong predilection for skin involvement.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • CD4 Antigens / analysis
  • CD56 Antigen / analysis
  • Cyclophosphamide / administration & dosage
  • Daunorubicin / administration & dosage
  • Daunorubicin / analogs & derivatives
  • Dexamethasone / administration & dosage
  • Doxorubicin / administration & dosage
  • Etoposide / administration & dosage
  • Humans
  • Immunophenotyping
  • Killer Cells, Natural / pathology*
  • Lymphoma, T-Cell, Cutaneous / diagnosis*
  • Lymphoma, T-Cell, Cutaneous / drug therapy
  • Lymphoma, T-Cell, Cutaneous / pathology
  • Male
  • Middle Aged
  • Pruritus / etiology
  • Remission Induction
  • Vincristine / administration & dosage

Substances

  • CD4 Antigens
  • CD56 Antigen
  • Vincristine
  • Etoposide
  • Dexamethasone
  • Doxorubicin
  • feudomycin D
  • Cyclophosphamide
  • Daunorubicin

Supplementary concepts

  • CVAD protocol