Abstract
The hypothalamic peptide orexin A (oxA) binds specifically the G-protein-coupled orexin receptor 1 (ox1R). It is involved in many physiological functions including the regulation of food intake, sleep-wake cycle, arterial blood pressure, heart rate, and sexual behavior. The localization of oxA in adrenal glands, stomach, bowel, pancreas, and testis has recently been assessed. Here, we provide the first evidence for the expression of oxA and ox1R in the vestibular glands of mammalian genital tract.
(c) 2008 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Blotting, Western
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Cattle
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DNA Primers / genetics
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Female
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Genitalia, Female / anatomy & histology
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Genitalia, Female / cytology
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Genitalia, Female / metabolism*
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Immunohistochemistry
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / metabolism*
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Neuroendocrine Cells / metabolism
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Neuropeptides / genetics
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Neuropeptides / metabolism*
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Orexin Receptors
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Orexins
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Receptors, G-Protein-Coupled / genetics
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Receptors, G-Protein-Coupled / metabolism*
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Receptors, Neuropeptide / genetics
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Receptors, Neuropeptide / metabolism*
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Reverse Transcriptase Polymerase Chain Reaction
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Tissue Distribution
Substances
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DNA Primers
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Orexin Receptors
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Orexins
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RNA, Messenger
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Receptors, G-Protein-Coupled
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Receptors, Neuropeptide