Abstract
ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.
MeSH terms
-
Adenosine Deaminase / genetics
-
Adenosine Deaminase / metabolism*
-
Animals
-
Apoptosis / physiology
-
Down-Regulation
-
Hematopoiesis / genetics*
-
Hematopoietic Stem Cells / physiology
-
Interferons / metabolism*
-
Lymphoid Progenitor Cells / physiology
-
Mice
-
Mice, Mutant Strains
-
RNA Editing*
-
RNA-Binding Proteins
Substances
-
RNA-Binding Proteins
-
Interferons
-
ADARB1 protein, human
-
Adenosine Deaminase