A new function for the RNA-editing enzyme ADAR1

Nat Immunol. 2009 Jan;10(1):16-8. doi: 10.1038/ni0109-16.

Abstract

ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.

Publication types

  • Comment

MeSH terms

  • Adenosine Deaminase / genetics
  • Adenosine Deaminase / metabolism*
  • Animals
  • Apoptosis / physiology
  • Down-Regulation
  • Hematopoiesis / genetics*
  • Hematopoietic Stem Cells / physiology
  • Interferons / metabolism*
  • Lymphoid Progenitor Cells / physiology
  • Mice
  • Mice, Mutant Strains
  • RNA Editing*
  • RNA-Binding Proteins

Substances

  • RNA-Binding Proteins
  • Interferons
  • ADARB1 protein, human
  • Adenosine Deaminase