Antimicrobial and cytotoxic activity of Marrubium alysson and Retama raetam grown in Tunisia

Pak J Biol Sci. 2007 May 15;10(10):1759-62. doi: 10.3923/pjbs.2007.1759.1762.

Abstract

Antibacterial and antifungal activities of extracts obtained from M. alysson, R. raetam were tested using a solid medium technique. We showed that the petroleum ether extract of M. alysson had a Minimum Inhibitory Concentration (MIC) varied from 128 to 2000 microg mL(-1) against different Enterobacteriaceae and antifungal activity against Candida glabrata, Candida albicans, Candida parapsilosis and Candida kreusei with a MIC of 256 microg mL(-1). The ethyl acetate extract of R. raetam showed the best activity against Gram positive organisms with MICs of 128 to 256 microg mL(-1) against methicillin resistant Staphylococcus aureus but low activity against the different Candida species.

MeSH terms

  • Animals
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology*
  • Candida / drug effects
  • Cell Survival / drug effects*
  • Chlorocebus aethiops
  • Genista / chemistry*
  • Marrubium / chemistry*
  • Microbial Sensitivity Tests
  • Plant Extracts / pharmacology*
  • Staphylococcus aureus / drug effects
  • Tunisia
  • Vero Cells

Substances

  • Anti-Infective Agents
  • Plant Extracts