A convenient three-component reaction leading to the synthesis of polysubstituted cyclohexene derivatives

Org Biomol Chem. 2008 Oct 7;6(19):3616-20. doi: 10.1039/b810299f. Epub 2008 Aug 4.

Abstract

A three-component reaction of beta-nitrostyrene, arylmethylidenemalononitrile and malononitrile catalyzed by imidazole produced the corresponding polysubstituted cyclohexene derivatives in moderate to good yields under mild conditions. A further improvement of this three-component reaction has also been achieved by starting from a commercially available aromatic aldehyde, nitromethane and malononitrile to give the products in moderate yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclohexenes / chemical synthesis*
  • Cyclohexenes / chemistry
  • Imidazoles / chemistry
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Cyclohexenes
  • Imidazoles
  • cyclohexene
  • imidazole