Ceramicines B-D, new antiplasmodial limonoids from Chisocheton ceramicus

Khalit Mohamad; Yusuke Hirasawa; Marc Litaudon; Khalijah Awang; A Hamid A Hadi; Koichi Takeya; Wiwied Ekasari; Aty Widyawaruyanti; Noor Cholies Zaini; Hiroshi Morita

doi:10.1016/j.bmc.2008.11.048

Ceramicines B-D, new antiplasmodial limonoids from Chisocheton ceramicus

Bioorg Med Chem. 2009 Jan 15;17(2):727-30. doi: 10.1016/j.bmc.2008.11.048. Epub 2008 Nov 24.

Authors

Khalit Mohamad¹, Yusuke Hirasawa, Marc Litaudon, Khalijah Awang, A Hamid A Hadi, Koichi Takeya, Wiwied Ekasari, Aty Widyawaruyanti, Noor Cholies Zaini, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan.

PMID: 19081726
DOI: 10.1016/j.bmc.2008.11.048

Abstract

Three new limonoids, ceramicines B-D (1-3), have been isolated from the bark of Chisocheton ceramicus. Structures and stereochemistry of 1-3 were fully elucidated and characterized by 2D NMR analysis. Ceramicines exhibited a moderate antiplasmodial activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / chemistry
Antiprotozoal Agents / isolation & purification*
Limonins / chemistry*
Limonins / isolation & purification
Limonins / pharmacology
Magnetic Resonance Spectroscopy
Plant Bark / chemistry*
Plasmodium / drug effects
Stereoisomerism
Structure-Activity Relationship

Substances

Antiprotozoal Agents
Limonins