Mobilization of qnrB2 and ISCR1 in plasmids

Antimicrob Agents Chemother. 2009 Mar;53(3):1235-7. doi: 10.1128/AAC.00970-08. Epub 2008 Dec 15.

Abstract

The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediated gene mobilization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Base Sequence
  • Conjugation, Genetic
  • Drug Resistance, Bacterial / genetics*
  • Enterobacter cloacae / enzymology
  • Enterobacter cloacae / genetics
  • Enterobacter cloacae / isolation & purification
  • Enterobacteriaceae Infections
  • Genes, Bacterial*
  • Humans
  • Molecular Sequence Data
  • Open Reading Frames
  • Plasmids*
  • Quinolones / pharmacology*
  • Sequence Analysis, DNA
  • beta-Lactamases / biosynthesis

Substances

  • Anti-Bacterial Agents
  • Quinolones
  • beta-Lactamases