Determination of atenolol at a graphite-polyurethane composite electrode

Priscila Cervini; Luiz Antônio Ramos; Eder Tadeu Gomes Cavalheiro

doi:10.1016/j.talanta.2006.10.017

Determination of atenolol at a graphite-polyurethane composite electrode

Talanta. 2007 Apr 15;72(1):206-9. doi: 10.1016/j.talanta.2006.10.017. Epub 2006 Nov 17.

Authors

Priscila Cervini¹, Luiz Antônio Ramos, Eder Tadeu Gomes Cavalheiro

Affiliation

¹ Universidade de Sao Paulo, Instituto de Quimica de Sao Carlos, Av. do Trabalhador Sancarlense, 400, 13566-590 Sao Carlos, SP, Brazil.

PMID: 19071603
DOI: 10.1016/j.talanta.2006.10.017

Abstract

A bare graphite-polyurethane composite was evaluated as an alternative electrode in the determination of atenolol (ATN) in pharmaceutical formulations. Using a DPV procedure, a linear analytical curve was observed in the 4-100mumolL(-1) range with a LOD=3.16mumolL(-1), without need of surface renewing between successive runs, with recoveries between 95.5 and 108%. Interference of other antihypertensive drugs was observed, but not from the usual components of tablets. The results of the proposed method agreed with HPLC ones within 95% confidence level.