A novel cyclic hexapeptide as chiral selector: Application for HPLC separation of a series of dansyl amino and arylalkanoic acids

Claire André; Mireille Thomassin; Arunalyat Umrayami; Lhassane Ismaili; Bernard Refouvelet; Yves-Claude Guillaume

doi:10.1016/j.talanta.2006.07.041

A novel cyclic hexapeptide as chiral selector: Application for HPLC separation of a series of dansyl amino and arylalkanoic acids

Talanta. 2007 Mar 15;71(4):1817-23. doi: 10.1016/j.talanta.2006.07.041. Epub 2006 Sep 1.

Authors

Claire André¹, Mireille Thomassin, Arunalyat Umrayami, Lhassane Ismaili, Bernard Refouvelet, Yves-Claude Guillaume

Affiliation

¹ Equipe des Sciences Séparatives et Biopharmaceutiques (2SB)-EA 3924, Laboratoire de Chimie Analytique, Faculté de Médecine Pharmacie, Place Saint Jacques, 25030 Besançon, Cedex, France.

PMID: 19071528
DOI: 10.1016/j.talanta.2006.07.041

Abstract

In this paper, the synthesis of a cyclic hexapeptide molecule was presented and evaluated for the enantiomer separation of a series of dansyl amino and arylalkanoic acids using high performance liquid chromatography (HPLC). It was clearly vizualized that this chiral selector allowed the separation of a great number of enantiomer pairs. The influences of the size and the hydrogen bonding donor (HBD) parameter of the organic modifier (OM) (THF (HBD=0.00), propan-2-ol (HBD=0.33), methanol (HBD=0.43)) added in the mobile phase were also investigated on both the enantiomer-chiral selector association and enantioseparation.