Enantioselective potentiometric membrane electrodes based on C(60) fullerene and its derivatives for the assay of l-Histidine

Raluca-Ioana Stefan-van Staden; Bhajan Lal; Luxolo Holo

doi:10.1016/j.talanta.2006.05.088

Enantioselective potentiometric membrane electrodes based on C(60) fullerene and its derivatives for the assay of l-Histidine

Talanta. 2007 Feb 28;71(3):1434-7. doi: 10.1016/j.talanta.2006.05.088. Epub 2006 Jul 7.

Authors

Raluca-Ioana Stefan-van Staden¹, Bhajan Lal, Luxolo Holo

Affiliation

¹ Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa.

PMID: 19071470
DOI: 10.1016/j.talanta.2006.05.088

Abstract

Novel enantioselective, potentiometric membrane electrodes (EPMEs) based on carbon paste impregnated with C(60) fullerene (I), (1,2-methanofullerene C60)-61-carboxylic acid (II), diethyl(1,2-methanofullerene C60)-61-61-dicarboxylate (III) and tert-butyl(1,2-methanofullerene C60)-61-carboxylic acid (IV) are reported. Response characteristics showed that the proposed electrodes could be reliably used in the assay of l-Histidine (l-His), with the best enantioselectivity and time-stability exhibited by fullerene derivatives. The surfaces of the electrodes are stable and easily renewable by simply polishing on an alumina paper. All proposed electrodes proved to be successful for the determination of the enantiopurity of histidine as raw material and of its pharmaceutical formulation.