Chlorogenic acid (CGA) could be a phenolic acid, which was widely found in food of plant origin and coffee drinks. The studies showed that biological activities of chlorogenic acid could be good for human health. The biological activity of regulating glucose and lipids metabolism and enhancing the sensitivity of insulin of CGA were focused the scientific evidence of preventing and treating the chronic diseases such as obesity and diabetes through the diet. The evolvement of study concerning the relation between CGA and glucose and lipids metabolism, and its mechanism were reviewed in this article.