Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet

Pediatr Transplant. 2009 Nov;13(7):919-22. doi: 10.1111/j.1399-3046.2008.01070.x. Epub 2008 Nov 1.

Abstract

We report an 18-yr-old female patient with repeated CMV reactivations after HSCT treated by several pre-emptive courses of virostatic therapy. Seven months after HSCT, she developed CMV encephalitis/retinitis. Initial therapy with GCV and hyperimmune globulin failed, and later on GCV-resistant strain was detected. Continual increase of CMV DNA in peripheral blood led us to combined therapy with CDV and FCV, which was successful and free of severe renal toxicity. To our best knowledge, this is the first reported case of successful CMV treatment with a combination of CDV and FCV.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antiviral Agents / therapeutic use*
  • Cidofovir
  • Cytomegalovirus Infections / complications
  • Cytomegalovirus Infections / drug therapy*
  • Cytomegalovirus Infections / etiology*
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use
  • Encephalitis, Viral / complications
  • Encephalitis, Viral / drug therapy*
  • Encephalitis, Viral / etiology*
  • Female
  • Foscarnet / therapeutic use*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hematopoietic Stem Cell Transplantation / methods
  • Humans
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / therapy
  • Organophosphonates / therapeutic use*
  • Retinitis / complications
  • Retinitis / drug therapy*
  • Retinitis / etiology*
  • Treatment Outcome

Substances

  • Antiviral Agents
  • Organophosphonates
  • Foscarnet
  • Cytosine
  • Cidofovir