A mutual regulation between cell-cell adhesion and N-glycosylation: implication of the bisecting GlcNAc for biological functions

J Proteome Res. 2009 Feb;8(2):431-5. doi: 10.1021/pr800674g.

Abstract

Changes in oligosaccharide structures are associated with numerous physiological and pathological events. E-cadherin-mediated cell-cell adhesion is believed to be both temporally and spatially regulated during development, and represents a key step in the acquisition of the invasive phenotype for many tumors. Here, we focus mainly on a mutual regulation between E-cadherin-mediated cell-cell adhesion and N-acetylglucosaminyltransferase III (GnT-III) expression, and discuss its implications for biological functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylglucosamine / chemistry
  • Acetylglucosamine / metabolism*
  • Animals
  • Cadherins / metabolism*
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Cell Adhesion / physiology*
  • Glycosylation
  • Models, Molecular
  • Molecular Sequence Data
  • N-Acetylglucosaminyltransferases / metabolism*

Substances

  • Cadherins
  • N-Acetylglucosaminyltransferases
  • beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
  • alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
  • Acetylglucosamine