Abstract
Changes in oligosaccharide structures are associated with numerous physiological and pathological events. E-cadherin-mediated cell-cell adhesion is believed to be both temporally and spatially regulated during development, and represents a key step in the acquisition of the invasive phenotype for many tumors. Here, we focus mainly on a mutual regulation between E-cadherin-mediated cell-cell adhesion and N-acetylglucosaminyltransferase III (GnT-III) expression, and discuss its implications for biological functions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetylglucosamine / chemistry
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Acetylglucosamine / metabolism*
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Animals
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Cadherins / metabolism*
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Carbohydrate Conformation
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Carbohydrate Sequence
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Cell Adhesion / physiology*
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Glycosylation
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Models, Molecular
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Molecular Sequence Data
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N-Acetylglucosaminyltransferases / metabolism*
Substances
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Cadherins
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N-Acetylglucosaminyltransferases
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beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
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alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase
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Acetylglucosamine