Cells of rhabdomyosarcoma PA-23 tumor clones with high and low metastatic potential differ by activity of lysosomal sialidase

S N Proshin; E V Kaminskaya; A A Lebedev; P D Shabanov

doi:10.1007/s10517-008-0090-x

Cells of rhabdomyosarcoma PA-23 tumor clones with high and low metastatic potential differ by activity of lysosomal sialidase

Bull Exp Biol Med. 2008 Mar;145(3):355-7. doi: 10.1007/s10517-008-0090-x.

Authors

S N Proshin¹, E V Kaminskaya, A A Lebedev, P D Shabanov

Affiliation

¹ Department of Cellular and Molecular Pathology, A. M. Nikiforov Russian Center of Emergency and Radiation Medicine, Ministry of Emergency Situations.

PMID: 19039943
DOI: 10.1007/s10517-008-0090-x

Abstract

We studied activity of lysosomal sialidase in cells of rhabdomyosarcoma PA-23 tumor clones with high and low metastatic potential. Low activity of lysosomal sialidase was found in clones characterized by high metastatic potential.

MeSH terms

Animals
Lysosomes / enzymology
Neoplasm Metastasis / pathology*
Neoplasm Metastasis / physiopathology
Neuraminidase / metabolism*
Rats
Rhabdomyosarcoma / enzymology*
Rhabdomyosarcoma / pathology*

Substances

Neuraminidase