A liposomal delivery vehicle for the anticancer agent gossypol

Anticancer Res. 2008 Sep-Oct;28(5A):2801-5.

Abstract

Background: Gossypol has recently been identified as a potential anticancer agent. In this study, a novel liposomal formulation is evaluated for delivery of gossypol.

Materials and methods: Gossypol was incorporated into liposomes. The liposomes were characterized for physical and chemical properties and for in vitro cytotoxicity.

Results: Gossypol was stably encapsulated in these liposomes and exhibited cytotoxicity towards cancer cells.

Conclusion: Liposomes can be used effectively as gossypol carriers.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Cell Line, Tumor
  • Gossypol / administration & dosage*
  • Gossypol / chemistry
  • HeLa Cells
  • Humans
  • KB Cells
  • Liposomes / administration & dosage*
  • Liposomes / chemistry
  • Phospholipids / administration & dosage
  • Phospholipids / chemistry

Substances

  • Antineoplastic Agents
  • Liposomes
  • Phospholipids
  • Gossypol