First observation of HIV type 1 drug resistance mutations in Algeria

AIDS Res Hum Retroviruses. 2008 Nov;24(11):1467-73. doi: 10.1089/aid.2008.0087.

Abstract

This study demonstrates for the first time HIV-1 resistance mutations to all classes of antiretroviral drugs available in Algeria (NRTIs, NNRTIs, PIs) in treated patients at failure. Moreover, it is shown that mutations to NRTIs and PIs can be observed in untreated patients in this country where there is high HIV-1 diversity.

MeSH terms

  • Algeria
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use
  • Drug Resistance, Viral*
  • HIV Infections / virology*
  • HIV Protease / genetics
  • HIV Reverse Transcriptase / genetics
  • HIV-1 / drug effects*
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Humans
  • Mutation, Missense*
  • Phylogeny
  • RNA, Viral / genetics*
  • Sequence Analysis, DNA
  • Sequence Homology
  • Treatment Failure

Substances

  • Anti-HIV Agents
  • RNA, Viral
  • HIV Reverse Transcriptase
  • HIV Protease
  • p16 protease, Human immunodeficiency virus 1