Abstract
Chaetoglobins A (1) and B (2), two azaphilone alkaloid dimers with an unprecedented skeleton, were characterized from an endophytic fungus Chaetomium globosum with the former ascertained to be a significant cytotoxin valuable for anti-tumor drug discovery.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology
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Chaetomium / chemistry*
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Drug Screening Assays, Antitumor
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Isoquinolines / chemistry*
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Isoquinolines / pharmacology
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Molecular Structure
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Pigments, Biological / chemistry
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Pigments, Biological / isolation & purification
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Pigments, Biological / pharmacology
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Tumor Cells, Cultured
Substances
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Alkaloids
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Antineoplastic Agents
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Benzopyrans
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Isoquinolines
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Pigments, Biological
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azaphilone
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chaetoglobin A
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chaetoglobin B