The case of a 60-years-old woman with coronary artery anomaly and factor V deficiency is reported. She presented with right radial artery pseudoaneurysm after coronary angiography. Her coronary angiography revealed aberrant origin of left anterior descending artery from right coronary cusp. On preliminary investigations her prothrombin time and activated partial thromboplastin time were prolonged. Her plasma factor V level was found out to be 4%, a moderate deficiency of factor V.