Comparison of cefoxitin and oxacillin disk diffusion methods for detection of mecA-mediated resistance in Staphylococcus aureus in a large-scale study

J Clin Microbiol. 2009 Jan;47(1):217-9. doi: 10.1128/JCM.01506-08. Epub 2008 Nov 19.

Abstract

The recommended breakpoints for the cefoxitin disk diffusion test for Staphylococcus aureus were recently modified. In this large-sample study, cefoxitin sensitivity and specificity compared to those of oxacillin were 97.3% and 100%, respectively. This study validated the new cefoxitin breakpoints for the detection of mecA-mediated resistance in S. aureus.

Publication types

  • Evaluation Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cefoxitin / pharmacology*
  • Humans
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Microbial Sensitivity Tests
  • Oxacillin / pharmacology*
  • Sensitivity and Specificity
  • Staphylococcal Infections / microbiology

Substances

  • Anti-Bacterial Agents
  • Cefoxitin
  • Oxacillin