Abstract
Oxaliplatin has been approved for adjuvant treatment of colorectal cancer. Toxicity induced by oxaliplatin is moderate and manageable, but some isolated cases of severe pulmonary toxicity associated to oxaliplatin have been reported. Two fatal cases of interstitial pneumonitis rapidly evolving to pulmonary fibrosis are reported here.
MeSH terms
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Adenocarcinoma / drug therapy
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Adenocarcinoma / secondary
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Adenocarcinoma / surgery
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Aged
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Antineoplastic Agents, Alkylating / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Combined Modality Therapy
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Fatal Outcome
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Female
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Fluorouracil / administration & dosage
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Granulomatosis with Polyangiitis / complications
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Humans
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Leucovorin / administration & dosage
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Lung Diseases, Interstitial / chemically induced*
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Lung Diseases, Interstitial / diagnostic imaging
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Lung Diseases, Interstitial / pathology
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Lung Neoplasms / drug therapy
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Lung Neoplasms / secondary
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Lung Neoplasms / surgery
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Male
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / adverse effects*
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Oxaliplatin
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Pneumonectomy
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Postoperative Complications / chemically induced
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Pulmonary Alveoli / pathology
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Pulmonary Fibrosis / chemically induced*
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Pulmonary Fibrosis / diagnostic imaging
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Pulmonary Fibrosis / pathology
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Respiratory Distress Syndrome / etiology
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Sigmoid Neoplasms / surgery
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Tomography, X-Ray Computed
Substances
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Antineoplastic Agents, Alkylating
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Organoplatinum Compounds
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Oxaliplatin
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Leucovorin
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Fluorouracil