Human papillomavirus in HNSCC: a European epidemiologic perspective

Hematol Oncol Clin North Am. 2008 Dec;22(6):1143-53, vii-viii. doi: 10.1016/j.hoc.2008.10.002.

Abstract

The aim of this study was to assess incidence and survival of human papillomavirus-related and unrelated head and neck squamous cell carcinoma sites from 15 European population-based cancer registries. This analysis was performed on 29,265 adult (aged approximately 15 years) cancer patients diagnosed in the period from 1988 to 2002. The human papillomavirus-unrelated cancer sites had an age-standardized incidence higher than the human papillomavirus-related cancer cases (3.8 versus 2.5/100,000 year). Incidence rates of head and neck squamous cell carcinomas increased more for human papillomavirus-related than unrelated cancer sites. Three-year survival rates improved more in human papillomavirus-related than unrelated cancer sites, and women had better rates of survival than men.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Squamous Cell* / mortality
  • Carcinoma, Squamous Cell* / therapy
  • Carcinoma, Squamous Cell* / virology
  • Disease-Free Survival
  • Europe
  • Head and Neck Neoplasms* / mortality
  • Head and Neck Neoplasms* / therapy
  • Head and Neck Neoplasms* / virology
  • Papillomaviridae
  • Papillomavirus Infections* / mortality
  • Papillomavirus Infections* / therapy
  • Papillomavirus Infections* / transmission
  • Survival Rate