Abstract
The separative and analytical power of ion mobility spectrometry-mass spectrometry combined with photo-induced cross-linking of site-specifically incorporated trifluoromethyldiazirine provides a powerful approach towards structural characterisation of amyloid fibrils.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amyloid / chemistry*
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Amyloid / ultrastructure
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / metabolism
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Azirines / chemistry*
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Cross-Linking Reagents / chemistry*
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Methane / analogs & derivatives
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Methane / chemistry
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Peptides / chemical synthesis
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Peptides / chemistry
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Phenylalanine / analogs & derivatives*
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Phenylalanine / chemical synthesis
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Phenylalanine / chemistry
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Protein Structure, Tertiary
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Spectrometry, Mass, Electrospray Ionization
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Ultraviolet Rays
Substances
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Amyloid
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Amyloid beta-Peptides
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Azirines
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Cross-Linking Reagents
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Peptides
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trifluoromethyldiazirine-phenylalanine
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carbene
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Phenylalanine
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Methane