Abstract
Eleven new thio-avarol derivatives (3-13) were synthesized. Their antimicrobial, brine shrimp lethality, and free-radical scavenging activities and acetylcholinesterase inhibition, together with 12 already reported semisynthetic thio-avarol derivatives (14-25), were evaluated. Structure-activity relationships among these thio derivatives were determined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Artemia / drug effects*
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Cholinesterase Inhibitors / chemical synthesis*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / pharmacology
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Dysidea / chemistry
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Free Radical Scavengers / chemical synthesis*
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology
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Microbial Sensitivity Tests
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology
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Structure-Activity Relationship
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Sulfur Compounds / chemical synthesis*
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Sulfur Compounds / chemistry
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Sulfur Compounds / pharmacology
Substances
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Anti-Infective Agents
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Cholinesterase Inhibitors
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Free Radical Scavengers
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Sesquiterpenes
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Sulfur Compounds
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avarol