A highly sensitive and selective OFF-ON fluorescent sensor for cadmium in aqueous solution and living cell

J Am Chem Soc. 2008 Dec 3;130(48):16160-1. doi: 10.1021/ja806928n.

Abstract

A highly selective and sensitive OFF-ON fluorescent sensor 1, employing the PET mechanism, was designed and synthesized. It could be used to detect Cd(2+) ion in aqueous solution and to image Cd(2+) ion in living cells. The fluorescence intensity significantly enhanced about 195-fold and the quantum yield increased almost 100-fold. Moreover the fluorescence intensity of 1 increased linearly with high sensitivity (0-1 microM) toward Cd(2+).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cadmium / chemistry*
  • Cell Survival
  • Fluorescent Dyes / analysis*
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Sensitivity and Specificity
  • Solutions
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Solutions
  • Cadmium