Abstract
Chemical investigation of the octocoral Sarcophyton ehrenbergi, collected at the Dongsha Islands, Taiwan, has led to the isolation of a known ceramide (1) and two new cerebrosides, sarcoehrenosides A (2) and B (4), along with three known cerebrosides (3, 5, and 6). The structures of the new compounds were established by spectroscopic and chemical methods. Sarcoehrenoside A (2) differs from previously known marine cerebrosides in that it possesses a rare alpha-glucose moiety. Compounds 1-6 were evaluated for antimicrobial activity against a small panel of bacteria and for anti-inflammatory activity using RAW 264.7 macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Ceramides / chemistry
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Ceramides / isolation & purification*
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Ceramides / pharmacology
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Cerebrosides / chemistry
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Cerebrosides / isolation & purification*
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Cerebrosides / pharmacology
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Enterobacter aerogenes / drug effects
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Macrophages / drug effects
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Salmonella enteritidis / drug effects
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Serratia marcescens / drug effects
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Shigella sonnei / drug effects
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Yersinia enterocolitica / drug effects
Substances
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Anti-Inflammatory Agents
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Ceramides
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Cerebrosides