Abstract
The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7'-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Butanes / chemistry*
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Butylene Glycols / chemistry
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Butylene Glycols / pharmacology*
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / pharmacology*
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Guaiacol / analogs & derivatives*
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Guaiacol / chemistry
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Guaiacol / pharmacology
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Lignans / chemistry
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Lignans / pharmacology*
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Lipoxygenase Inhibitors / chemistry
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Lipoxygenase Inhibitors / pharmacology
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Oxidation-Reduction
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Stereoisomerism
Substances
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7,7'-oxodihydroguaiaretic acid
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Butanes
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Butylene Glycols
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Free Radical Scavengers
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Lignans
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Lipoxygenase Inhibitors
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dihydroguaiaretic acid
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Guaiacol
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secoisolariciresinol