Urinary excretion of ganciclovir contributes to improvement of adenovirus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Yozo Nakazawa; Takefumi Suzuki; Tetsuhiro Fukuyama; Yoshihiko Katsuyama; Miyuki Tanaka; Ryu Yanagisawa; Kazuo Sakashita; Masaaki Shiohara; Kenichi Koike

doi:10.1111/j.1399-3046.2008.01027.x

Urinary excretion of ganciclovir contributes to improvement of adenovirus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation

Pediatr Transplant. 2009 Aug;13(5):632-5. doi: 10.1111/j.1399-3046.2008.01027.x. Epub 2008 Oct 7.

Authors

Yozo Nakazawa¹, Takefumi Suzuki, Tetsuhiro Fukuyama, Yoshihiko Katsuyama, Miyuki Tanaka, Ryu Yanagisawa, Kazuo Sakashita, Masaaki Shiohara, Kenichi Koike

Affiliation

¹ Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

PMID: 18992066
DOI: 10.1111/j.1399-3046.2008.01027.x

Abstract

A nine-yr-old girl developed AdV-associated HC after bone marrow transplantation. Intravenous GCV markedly reduced urinary AdV DNA loads and improved clinical findings. This appeared to result partly from a high concentration of GCV in urine. GCV may be effective for AdV-induced HC without definitive disseminated infection.

Publication types

Case Reports

MeSH terms

Adenoviridae / metabolism*
Adenoviridae Infections / diagnosis
Adenoviridae Infections / urine
Bone Marrow Transplantation / adverse effects*
Cell Line, Tumor
Child
Cystitis / drug therapy*
Cystitis / virology
Female
Ganciclovir / therapeutic use
Ganciclovir / urine*
Humans
Immunosuppressive Agents / therapeutic use
Leukemia, Myeloid, Acute / therapy*
Risk Factors
Transplantation, Homologous

Substances

Immunosuppressive Agents
Ganciclovir