Demethoxycurcumin and its semisynthetic analogues as antitubercular agents

Dinesh Kumar Agrawal; Dharmendra Saikia; Richa Tiwari; Shweta Ojha; Karuna Shanker; Jonnala Kotesh Kumar; Anil Kumar Gupta; Sudeep Tandon; Arvind Singh Negi; Suman Preet Khanuja

doi:10.1055/s-0028-1088335

Demethoxycurcumin and its semisynthetic analogues as antitubercular agents

Planta Med. 2008 Dec;74(15):1828-31. doi: 10.1055/s-0028-1088335. Epub 2008 Nov 7.

Authors

Dinesh Kumar Agrawal¹, Dharmendra Saikia, Richa Tiwari, Shweta Ojha, Karuna Shanker, Jonnala Kotesh Kumar, Anil Kumar Gupta, Sudeep Tandon, Arvind Singh Negi, Suman Preet Khanuja

Affiliation

¹ Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Lucknow, India.

PMID: 18991209
DOI: 10.1055/s-0028-1088335

Abstract

Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strain MIC:minimum inhibitory concentration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / isolation & purification
Antitubercular Agents / pharmacology*
Curcuma / chemistry*
Curcumin / analogs & derivatives*
Curcumin / isolation & purification
Curcumin / pharmacology
Diarylheptanoids
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Plant Extracts / isolation & purification
Plant Extracts / pharmacology*
Rhizome

Substances

Antitubercular Agents
Diarylheptanoids
Plant Extracts
Curcumin
demethoxycurcumin