Abstract
A 55-year-old man presented with generalized seizures and postictal left hemiparesis. Computed tomography scanning of his head showed a low density area in the right frontal lobe. Cerebral angiography demonstrated a partial defect in the superior sagittal sinus and cortical veins, indicating the presence of cerebral venous thrombosis. He had bleeding from a peptic ulcer and the laboratory data revealed iron deficiency anemia concomitant with an elevation of D-dimer and thrombin-antithrombin III complex (TAT). After the anemia resolved with the treatment of the peptic ulcer and iron supplementation, the TAT and D-dimer levels were normalized, and the occluded veins were recanalized. In a cerebral venous thrombosis associated with iron deficiency anemia, treatment for the anemia may improve hypercoagulable state without antithrombotic therapy, although the long-term monitoring of TAT and D-dimer levels is required.
MeSH terms
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Anemia, Iron-Deficiency / complications*
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Anemia, Iron-Deficiency / physiopathology
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Antithrombin III
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Blood Coagulation Disorders / complications
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Blood Coagulation Disorders / etiology
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Blood Coagulation Disorders / physiopathology
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Brain / blood supply
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Brain / diagnostic imaging
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Brain / pathology
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Cerebral Angiography
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Cerebral Veins / diagnostic imaging
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Cerebral Veins / pathology*
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Cerebral Veins / physiopathology
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Dietary Supplements
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Humans
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Iron / therapeutic use
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Male
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Middle Aged
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Paresis / diagnostic imaging
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Paresis / etiology
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Paresis / physiopathology
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Peptic Ulcer / etiology
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Peptic Ulcer / pathology
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Peptic Ulcer / physiopathology
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Peptide Hydrolases / blood
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Seizures / etiology
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Seizures / physiopathology
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Treatment Outcome
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Venous Thrombosis / etiology*
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Venous Thrombosis / pathology*
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Venous Thrombosis / physiopathology
Substances
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antithrombin III-protease complex
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Antithrombin III
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Iron
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Peptide Hydrolases