A protein-only RNase P in human mitochondria

Cell. 2008 Oct 31;135(3):412-4. doi: 10.1016/j.cell.2008.10.010.

Abstract

In bacteria, archaea, and the eukaryote nucleus, the endonuclease ribonuclease P (RNase P) is composed of a catalytic RNA that is assisted by protein subunits. Holzmann et al. (2008) now provide evidence that the human mitochondrial RNase P is an entirely protein-based enzyme.

Publication types

  • Comment

MeSH terms

  • Evolution, Molecular
  • Humans
  • Mitochondria / enzymology*
  • RNA, Catalytic / analysis*
  • Ribonuclease P / chemistry*
  • Ribonuclease P / metabolism

Substances

  • RNA, Catalytic
  • Ribonuclease P