Abstract
High-throughput screening resulted in the identification of a series of novel motilin receptor agonists with relatively low molecular weights. The series originated from an array of biphenyl derivatives designed to target 7-transmembrane (7-TM) receptors. Further investigation of the structure-activity relationship within the series resulted in the identification of compound (22) as a potent and selective agonist at the motilin receptor.
MeSH terms
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Animals
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Binding Sites
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Cell Membrane / metabolism
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Chemistry, Pharmaceutical / methods
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Combinatorial Chemistry Techniques
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Drug Design
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Drug Evaluation, Preclinical
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Humans
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Models, Chemical
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Molecular Structure
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Receptors, G-Protein-Coupled / metabolism
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Receptors, Gastrointestinal Hormone / agonists*
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Receptors, Gastrointestinal Hormone / chemistry*
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Receptors, Neuropeptide / agonists*
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Receptors, Neuropeptide / chemistry*
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Recombinant Proteins / chemistry
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Structure-Activity Relationship
Substances
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Receptors, G-Protein-Coupled
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Receptors, Gastrointestinal Hormone
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Receptors, Neuropeptide
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Recombinant Proteins
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motilin receptor