Objective: To summarize the effect of self-setting CPC on the repair of bone defect after tumor resection in children.
Methods: From December 1998 to December 2006, 32 patients with benign bone tumor were treated, and the bone defect was repaired by CPC. Among them, there were 21 males and 11 females, aged 4-14 years old (9.8 on average). The course of disease was 3-18 months. There were 12 cases of non-ossifying fibroma, 8 of bone cyst, 7 of osteoid osteoma and 5 of fibrous dysplasia. The bone defect was located in femur in 15 cases, in tibia in 8 cases, in humerus in 6 cases and in other positions in 3 cases. The range of bone defect was 2.0 cm x 1.5 cm x 1.0 cm - 10.0 cm x 5.0 cm x 4.0 cm. CPC spongiosa granules of 3-23 g were filled in 26 cases, including 3 children with pathologic fracture and internal fixation with plate, and injectable CPC of 5-20 mL was filled in 6 bone cyst cases.
Results: Thirty-two patients obtained healing by first insertion. All the patients were followed up for 12-48 months (23.5 months on average). No allergic reaction, toxicity, rash or high fever was found after operation. There was no pain or pruritus at the incisions. The X-ray films showed that the implanted CPC began to fuse with the host bone 4-9 months (7 month on average) after operation. The internal fixation was removed within 6-12 months of operation. And CPC spongiosa granules were absolutely absorbed within 8-36 months of operation. However, injectable CPC could be found 4 years after operation. The children's limbs could do normal exercises. Finally, bone matrix grew well and no recurrence was found.
Conclusion: CPC in repairing bone defect after benign bone tumor in children is a safe, economical, convenient and non-toxic method.