Abstract
To evaluate the effect of various chemotherapy courses on the rate of bloodstream infections (BSI) during therapy-related neutropenia, all infection episodes of adult patients with acute myeloid leukaemia (AML) during 7 y were retrospectively analysed in a university hospital. Of the 182 infection episodes in 76 AML patients, 37% (n = 68) were BSI. The riskratio (RR) of BSI was highest after regimens containing high-dose cytarabine (2.4 with 95% confidence interval (CI) 1.3-4.4) and lowest after thioguanine-containing courses (RR: 0.2, 95% CI 0.2-0.5). Chemotherapy courses per se may have an influence on the rate of BSI during neutropenia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bacteremia / epidemiology
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Bacteremia / etiology*
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Female
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Flow Cytometry
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Fungemia / epidemiology
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Fungemia / etiology
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Gram-Negative Bacteria / isolation & purification
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Gram-Positive Bacteria / isolation & purification
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Humans
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Leukemia, Myeloid, Acute / complications*
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Leukemia, Myeloid, Acute / drug therapy*
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Male
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Middle Aged
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Neutropenia / chemically induced*
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Statistics, Nonparametric
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Yeasts / isolation & purification
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Young Adult