Influence of chemotherapy courses on the rate of bloodstream infections during neutropenia in adult acute myeloid leukaemia

Scand J Infect Dis. 2008;40(8):642-7. doi: 10.1080/00365540801947338.

Abstract

To evaluate the effect of various chemotherapy courses on the rate of bloodstream infections (BSI) during therapy-related neutropenia, all infection episodes of adult patients with acute myeloid leukaemia (AML) during 7 y were retrospectively analysed in a university hospital. Of the 182 infection episodes in 76 AML patients, 37% (n = 68) were BSI. The riskratio (RR) of BSI was highest after regimens containing high-dose cytarabine (2.4 with 95% confidence interval (CI) 1.3-4.4) and lowest after thioguanine-containing courses (RR: 0.2, 95% CI 0.2-0.5). Chemotherapy courses per se may have an influence on the rate of BSI during neutropenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bacteremia / epidemiology
  • Bacteremia / etiology*
  • Female
  • Flow Cytometry
  • Fungemia / epidemiology
  • Fungemia / etiology
  • Gram-Negative Bacteria / isolation & purification
  • Gram-Positive Bacteria / isolation & purification
  • Humans
  • Leukemia, Myeloid, Acute / complications*
  • Leukemia, Myeloid, Acute / drug therapy*
  • Male
  • Middle Aged
  • Neutropenia / chemically induced*
  • Statistics, Nonparametric
  • Yeasts / isolation & purification
  • Young Adult

Substances

  • Antineoplastic Agents