Cylindradines A and B: novel bromopyrrole alkaloids from the marine sponge Axinella cylindratus

Makoto Kuramoto; Norimichi Miyake; Yoshihisa Ishimaru; Noboru Ono; Hidemitsu Uno

doi:10.1021/ol802263j

Cylindradines A and B: novel bromopyrrole alkaloids from the marine sponge Axinella cylindratus

Org Lett. 2008 Dec 4;10(23):5465-8. doi: 10.1021/ol802263j.

Authors

Makoto Kuramoto¹, Norimichi Miyake, Yoshihisa Ishimaru, Noboru Ono, Hidemitsu Uno

Affiliation

¹ Department of Molecular Science, Integrated Center for Sciences, Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan. kuramoto@dpc.ehime-u.ac.jp

PMID: 18975955
DOI: 10.1021/ol802263j

Abstract

The novel alkaloids cylindradines A and B were isolated from Axinella cylindratus, and their structures were elucidated by spectroscopic analyses. Stereochemistries of these compounds were determined by X-ray analysis. Cylindradines showed moderate inhibitory activity against the murine leukemia cell line P388.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Animals
Axinella / chemistry*
Cell Line, Tumor
Chromatography, High Pressure Liquid
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Mice
Pyrroles / chemistry*
Pyrroles / isolation & purification
Pyrroles / pharmacology

Substances

Alkaloids
Pyrroles
cylindradine A
cylindradine B