Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

N T Woo; S Y Jin; D J Cho; N S Kim; E H Bae; D Han; B H Han; Y H Kang

doi:10.1007/BF02974047

Synthesis of substituted cinnamoyl-tyramine derivatives and their platelet anti-aggregatory activities

Arch Pharm Res. 1997 Feb;20(1):80-4. doi: 10.1007/BF02974047.

Authors

N T Woo¹, S Y Jin, D J Cho, N S Kim, E H Bae, D Han, B H Han, Y H Kang

Affiliation

¹ Il-Yang Central Research Institute, Hagal 182-4, Kiheung, Yongin, 449-900, Kyungki, Korea.

PMID: 18975217
DOI: 10.1007/BF02974047

Abstract

Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.