The facile and efficient synthesis of 8-chloroadenosine 3',5'-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by(1)H and (13)C NMR spectroscopy

N T Woo; S Y Jin; D J Cho; N S Kim; E H Bae; J H Jung; W H Ham; Y H Jung

doi:10.1007/BF02974006

The facile and efficient synthesis of 8-chloroadenosine 3',5'-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by(1)H and (13)C NMR spectroscopy

Arch Pharm Res. 1997 Apr;20(2):176-9. doi: 10.1007/BF02974006.

Authors

N T Woo¹, S Y Jin, D J Cho, N S Kim, E H Bae, J H Jung, W H Ham, Y H Jung

Affiliation

¹ II-Yang Central Research Institute, Hagal 182-4, Kiheung, 449-900, Yongin, Kyungki, Korea.

PMID: 18975197
DOI: 10.1007/BF02974006

Abstract

Purine nucleosides were chlorinated by the reaction of acyl chloride in DMF with MCPBA under mild conditions with moderate yields. And, satisfactory method for the synthesis of ribonucleoside-3',5'-cyclic phosphates and its characterization by(1)H and(13)C nmr spectroscopy is described.