Synthesis of 6H-indolo[2,3-b]quinoxaline-N-glycosides and their cytotoxic activity against human ceratinocytes (HaCaT)

Org Biomol Chem. 2008 Nov 21;6(22):4218-23. doi: 10.1039/b812308j. Epub 2008 Sep 11.

Abstract

N-glycosides of 6H-indolo[2,3-b]quinoxalines were prepared and structurally characterized. The synthesis relies on the cyclocondensation of isatine-N-glycosides with 1,2-diaminobenzenes. Some products exhibit weak cytotoxic activity against human ceratinocytes (HaCaT).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glycosides / chemical synthesis*
  • Glycosides / chemistry
  • Glycosides / toxicity*
  • Humans
  • Indoles / chemistry*
  • Keratinocytes / drug effects*
  • Quinoxalines / chemistry*

Substances

  • Glycosides
  • Indoles
  • Quinoxalines
  • indole