Electro-oxidation of glucose at self-assembled monolayers incorporated by copper particles

Jia Zhao; Fang Wang; Jingjing Yu; Shengshui Hu

doi:10.1016/j.talanta.2006.03.004

Electro-oxidation of glucose at self-assembled monolayers incorporated by copper particles

Talanta. 2006 Sep 15;70(2):449-54. doi: 10.1016/j.talanta.2006.03.004. Epub 2006 Apr 18.

Authors

Jia Zhao¹, Fang Wang, Jingjing Yu, Shengshui Hu

Affiliation

¹ College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 100080, China.

PMID: 18970791
DOI: 10.1016/j.talanta.2006.03.004

Abstract

A novel copper incorporated self-assembled monolayers (SAMs) modified gold electrode (Cu/SAMs) for determination of glucose was developed by electrodepositing Cu particles on the SAMs of hexanethiol. The scanning electron microscopic (SEM) images showed that copper formed orbicular particles of nanosizes on the SAMs, which was much different from the fractal-like particles of copper formed at gold electrode. The Cu/SAMs film electrode exhibited high sensitivity to glucose oxidation and depressed responses towards some interferents of glucose in blood like uric acid and ascorbic acid. Under optimal working conditions, the oxidation current of glucose was proportional to the concentration of glucose in the range from 3.0muM to 10mM by amperometry with a low detection limit of 0.7muM glucose (S/N=3). This electrode was successfully applied to the determination of glucose in rat blood and the results were satisfactory.