Background: The effect of nail polish on pulse oximetry measurements in non-hypoxic subjects has been studied extensively. Some studies found that nail polish decreased pulse-oximetry (S(pO(2))) values, whereas others found no effects from nail polish.
Objective: To determine if nail polish affects S(pO(2)) measurements in mildly hypoxic subjects.
Methods: At high altitude, 5 investigators, whose mean oxygen saturation was 91.3% (mild hypoxia), and with 2 brands of pulse oximeter and oximetry probe, obtained S(pO(2)) measurements from a finger with nail polish and from the matching finger on the opposite hand without nail polish. We tested 9 different nail-polish colors and made 210 pairs of S(pO(2)) measurements.
Results: The mean +/- SD S(pO(2)) values from the fingers with and without nail polish, respectively, were 91.4+/-4.1% and 91.2+/-3.5% (difference 0.2+/-3.2%, 95% confidence interval -0.2% to 0.4%).
Conclusions: With the pulse oximeters and oximetry probes we tested, nail-polish had no significant effect on S(pO(2)) in mildly hypoxic healthy subjects.