Energetics of kinesin-1 stepping mechanism

FEBS Lett. 2008 Nov 12;582(27):3719-22. doi: 10.1016/j.febslet.2008.10.019. Epub 2008 Oct 21.

Abstract

Kinesin-1 is a dimeric motor protein that transports cellular cargo along microtubules by using the energy released from ATP hydrolysis and moving processively in 8-nm steps. Recent novel studies at the single molecular level have provided extensive knowledge on how kinesin-1 converts the free energy of ATP hydrolysis and uses it for "walking" along microtubules. In this review, I have discussed the important topics pertaining to the energetics of kinesin-1 stepping mechanism and the consensus walking model.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Amino Acid Sequence
  • Kinesins / chemistry
  • Kinesins / metabolism*
  • Motion*

Substances

  • Adenosine Triphosphate
  • Kinesins