Sepsis and septic shock are major contributors to mortality in children worldwide. While many factors may contribute to poor outcomes, resource limitations play a role in developing countries. However, early recognition and aggressive therapy using simple measures can reverse shock in most children. Indeed, great gains have been realized in some areas with limited resources. In this manuscript, the significant gains over the last few years are outlined, and issues to consider in resource limited environments are discussed. In addition, an invitation is extended to participate in a global sepsis initiative.