Abstract
We report a case of cerebral venous thrombosis (CVT) due to tyrotoxicosis in a patient with methylenetetrahydro-folate-reductase (MTHFR) gene polymorphism C677T, (genotype 677TT), in which discontinuation of intravenous heparin was followed by clinical and radiological worsening despite warfarin treatment. We discuss the relationship between CVT, MTHFR hyperthiroidism and anticoagulant therapy.
MeSH terms
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Adult
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Anticoagulants / therapeutic use
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Heparin / therapeutic use
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Humans
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Male
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Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
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Polymorphism, Genetic*
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Sinus Thrombosis, Intracranial / drug therapy
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Sinus Thrombosis, Intracranial / etiology*
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Sinus Thrombosis, Intracranial / genetics*
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Thyrotoxicosis / complications*
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Thyrotoxicosis / genetics
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Warfarin / therapeutic use
Substances
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Anticoagulants
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Warfarin
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Heparin
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Methylenetetrahydrofolate Reductase (NADPH2)