Detection of a brain lesion is the first diagnostic step in patients with symptoms and signs suggesting the presence of a brain tumour. Imaging is primarily done to prove or rule out the presence of such a lesion. The first diagnostic evaluation is based on neuroradiological imaging, and when the diagnosis of brain tumour is highly suspicious, the type of tumour should be characterized along with its grade of malignancy, as morphological imaging alone in not specific enough to give full comprehension of brain lesions. In recent years, after continuous developments in MRI, neuroimaging has evolved into a comprehensive diagnostic tool that allows the characterization of morphological and biological alterations to diagnose and grade brain tumours and to monitor and assess treatment response and patient prognosis.