Abstract
A short, flexible synthesis of the marine natural product (2 R)-(Z)-dysidazirine (-)-1 has been completed. (-)-1 shows significant antifungal activity across a panel of seven human pathogens, whereas the structural analogue (-)-2, featuring a terminal tert-butyl group, is essentially inactive.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Azirines / chemical synthesis*
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Azirines / chemistry
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Azirines / pharmacology*
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Fungi / drug effects
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Stereoisomerism
Substances
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Antifungal Agents
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Azirines
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dysidazirine