The purpose of this study is to examine the relationship between methamphetamine use and homicide. To carry out this study, data from the National Household Survey on Drug Abuse and Survey of Inmates in State and Federal Correctional Facilities were combined to create a case-control design. The main exposure measure is methamphetamine use and the main outcome measure is homicide. Results suggest that the odds of committing a homicide are nearly 9 times greater for an individual who uses methamphetamine. More importantly, the association between methamphetamine use and homicide persists even after adjusting for alternative drug use (i.e., alcohol, heroin, crack, cocaine, PCP, LSD), sex, race, income, age, marital status, previous arrests, military experience, and education level. Methamphetamine was the only drug use variable that was strongly correlated with homicide. These results support recent clinical studies that suggest methamphetamine use is different than other drug use in its effects on violence.