Abstract
Two partially purified organic fractions designated by PR1 and PR2 of the fat free ethanol (95%) extract of aerial parts of Phyllanthus reticulatus were tested for the hepatoprotective activity in rats against CCl(4)-induced liver damage. The rats receiving the fractions showed promising hepatoprotective activity as evident from significant changes of pentobarbital-induced sleeping time, changes in serum levels of sGPT, sGOT, sALP and bilirubin and also from histopathological changes as compared to CCl(4)-intoxicated rats.
MeSH terms
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Animals
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Biomarkers / blood
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Carbon Tetrachloride
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Chemical and Drug Induced Liver Injury
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Disease Models, Animal
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Euphorbiaceae* / chemistry
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Hypnotics and Sedatives / pharmacology
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Liver / drug effects*
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Liver / enzymology
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Liver / pathology
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Liver Diseases / metabolism
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Liver Diseases / pathology
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Liver Diseases / prevention & control*
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Male
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Necrosis
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Phenobarbital / pharmacology
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Plant Components, Aerial
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Protective Agents / isolation & purification
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Protective Agents / pharmacology*
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Rats
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Rats, Long-Evans
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Sleep / drug effects
Substances
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Biomarkers
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Hypnotics and Sedatives
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Protective Agents
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Carbon Tetrachloride
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Phenobarbital