Drug-eluting stents (DES) have had a profound impact on the practice of interventional cardiology. Important safety concerns regarding DES have been widely publicized and acknowledged. The primary emphasis has been placed on late stent thrombosis and the adverse sequela which result. Another emerging adverse effect of DES is coronary aneurysm (CAA) formation. We report on a patient who developed CAA formation after DES implantation but not at the site of previous bare-metal stent (BMS) implantation. We also review the current understanding of DES-associated CAA formation.