Synthesis of marine natural products with antimalarial activity

Mini Rev Med Chem. 2008 Oct;8(12):1265-84. doi: 10.2174/138955708786141007.

Abstract

The role played by synthetic organic chemistry of marine metabolites as potential leads for drug discovery of antimalarial agents is discussed. Syntheses of the most promising molecules are summarized, with emphasis on structure-activity relationship (SAR) studies and their mechanism of action.

Publication types

  • Review

MeSH terms

  • Animals
  • Antimalarials / pharmacology*
  • Antiprotozoal Agents / pharmacology*
  • Biological Products / chemical synthesis*
  • Biological Products / chemistry
  • Chemistry, Organic / methods
  • Chemistry, Pharmaceutical / methods*
  • Drug Design
  • Humans
  • Immunologic Factors / chemistry
  • Ketones
  • Models, Chemical
  • Nitriles / chemistry
  • Peroxides / metabolism
  • Structure-Activity Relationship

Substances

  • Antimalarials
  • Antiprotozoal Agents
  • Biological Products
  • Immunologic Factors
  • Ketones
  • Nitriles
  • Peroxides