OMA-gosh, where's that TAF?

T Keith Blackwell; Amy K Walker

doi:10.1016/j.cell.2008.09.021

OMA-gosh, where's that TAF?

Cell. 2008 Oct 3;135(1):18-20. doi: 10.1016/j.cell.2008.09.021.

Authors

T Keith Blackwell¹, Amy K Walker

Affiliation

¹ Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA. keith.blackwell@joslin.harvard.edu

PMID: 18854150
DOI: 10.1016/j.cell.2008.09.021

Abstract

How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition between maternal and zygotic gene expression.

Publication types

Comment

MeSH terms

Animals
Caenorhabditis elegans / embryology*
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins / metabolism*
Carrier Proteins / metabolism*
Gene Expression Regulation, Developmental
Gene Silencing*
Transcription Factors / metabolism*
Transcription, Genetic
Zygote / metabolism

Substances

Caenorhabditis elegans Proteins
Carrier Proteins
OMA-1 protein, C elegans
TAF-4 protein, C elegans
Transcription Factors
oma-2 protein, C elegans