Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress

Neurosci Lett. 2008 Dec 12;447(2-3):167-71. doi: 10.1016/j.neulet.2008.09.079. Epub 2008 Oct 5.

Abstract

Because the etiopathology of neurodegenerative diseases is tightly connected with oxidative stress, there is an increasing need to find compounds that might elicit an antioxidant and neuroprotective response in neurons. We found that nordihydroguaiaretic acid (NDGA), a powerful antioxidant from Larrea tridentate, activates the antioxidant pathway Nrf2/heme oxygenase-1 (HO-1) in cerebellar granule neurons and protects them against H(2)O(2) or 3-nitropropionic acid-induced neurotoxicity. The role of HO-1 in this protective effect was made evident by using an HO inhibitor, tin-mesoporphyrin. Our study identifies NDGA as a new potential therapeutic tool to activate the Nrf2/HO-1 axis for protection against oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Antioxidants / pharmacology*
  • Cells, Cultured
  • Cerebellum / cytology*
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • Heme Oxygenase (Decyclizing) / genetics
  • Heme Oxygenase (Decyclizing) / metabolism*
  • Hydrogen Peroxide / pharmacology
  • Masoprocol / pharmacology*
  • Mesoporphyrins / pharmacology
  • NF-E2-Related Factor 2 / genetics
  • NF-E2-Related Factor 2 / metabolism*
  • Neurons / drug effects*
  • Nitro Compounds / pharmacology
  • Oxidative Stress / drug effects*
  • Propionates / pharmacology
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Wistar
  • Signal Transduction / drug effects*
  • Time Factors

Substances

  • Antioxidants
  • Enzyme Inhibitors
  • Mesoporphyrins
  • NF-E2-Related Factor 2
  • Nitro Compounds
  • Propionates
  • RNA, Messenger
  • mesoporphyrin IX
  • Masoprocol
  • Hydrogen Peroxide
  • Heme Oxygenase (Decyclizing)
  • Hmox1 protein, rat
  • 3-nitropropionic acid